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The a16z Show

Andreessen Horowitz

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The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

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Sample fetched 2026-10-19 23:19:34.281 UTC · 24 cached episodes

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Oct 19, 2026 · UTC

What Happens When Al Agents Can Spend Your Money?

Why hasn't AI transformed everyday work as quickly as coding? Town CEO Jean-Denis Greze argues the bottleneck isn't intelligence, but making AI useful to people who don't have the time or technical skills to build their own automations.Jean-Denis joins a16z General Partner Alex Rampell to share why he pivoted Town from tax software to a personal AI…

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Oct 18, 2026 · UTC

Why Real-World AI Is Harder Than the Benchmark | EliseAI’s Mario Martone

What changes when an AI mistake doesn’t just hurt a benchmark score, but affects someone’s housing or healthcare? EliseAI Head of Applied Research Mario Martone argues that deploying AI in essential industries requires a very different standard of reliability.Mario joins MTS to explain how EliseAI handles roughly 5 million phone calls a month, why …

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Oct 17, 2026 · UTC

Why AI Could Finally Fix Healthcare Access | Zocdoc CEO Oliver Kharraz

Why is booking a doctor's appointment still so difficult, and can AI finally change that? Zocdoc CEO Oliver Kharraz argues that the real problem isn't finding doctors, but connecting patients to accurate availability and making appointments bookable wherever they start their search.Oliver joins a16z General Partner Julie Yoo to discuss how Zocdoc s…

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Oct 16, 2026 · UTC

AI Can Write the Code. Can It Run the System? | Grepr CEO Jad Naous

a16z General Partner Martin Casado sits down with Grepr CEO Jad Naous to ask what comes after AI learns to write code: can it also debug and operate the systems that code creates?Jad shares how AI has transformed engineering inside his 10-person team, cutting some projects from six months to just 10 days. But operating production systems is a harde…

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Oct 15, 2026 · UTC

When AI Agents Start Spending Your Money | Alex Rampell & Terry Angelos

a16z General Partner Alex Rampell sits down with VGS Executive Board Member, Terry Angelos, to unpack what happens to payments when AI agents go from recommending what to buy to actually making the purchase.Terry explains the infrastructure required to safely give agents access to payment credentials, why wallets like PayPal, Shop Pay, and Link are…

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Oct 14, 2026 · UTC

Can Open Models Keep Up With the AI Frontier? | Nathan Lambert

a16z Partner Lisha Li sits down with AI researcher and Trillium founder Nathan Lambert to ask how durable the gap really is between frontier AI labs and open models.Nathan argues that OpenAI and Anthropic have structural advantages in compute, capital, and the ability to pioneer new training paradigms, but open-model labs, particularly in China, ha…

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Oct 13, 2026 · UTC

Can AI Break Cryptography? What the Experts Actually Think

Could AI break the cryptography protecting everything from crypto wallets and banking to private messages? Recent advances in AI-driven mathematical research have sparked new warnings about the security of today's encryption systems, but how much of the concern is supported by evidence?a16z crypto's Liz Harkavy is joined by Stanford cryptographer D…

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Oct 12, 2026 · UTC

The Race to Recursive Self-Improving AI

a16z General Partner Martin Casado sits down with MakerMaker.AI co-founders Dhaval Adjodah and Owen He to unpack recursive self-improvement, or RSI, and separate the increasingly popular term from what it would actually mean for an AI system to improve itself.Dhaval and Owen distinguish true RSI from simply using AI to automate pieces of AI develop…

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Oct 11, 2026 · UTC

Nick Bostrom: How Should We Navigate Superintelligence?

Nick Bostrom joins Theo Jaffee and Sofia Puccini on MTS to revisit the ideas about superintelligence and existential risk that he helped bring into the mainstream, now that increasingly capable AI systems actually exist.Nick discusses why reinforcement learning may be pushing models toward more goal-seeking behavior, what recent agent experiments t…

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Oct 10, 2026 · UTC

What Makes a Great Entrepreneur? | Ben Horowitz on Vintage x Vintage

a16z co-founder and General Partner Ben Horowitz joins James Norman on the inaugural episode of Vintage x Vintage for a conversation spanning entrepreneurship, investing, hip-hop, and what changes when AI makes building dramatically easier.Ben reflects on going from Netscape to becoming a first-time CEO, why every founder eventually hits a “we’re f…

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Oct 9, 2026 · UTC

Chips, Memory, and Power | Pat Gelsinger

a16z's Raghu Raghuram and Guido Appenzeller sit down with Playground Global General Partner and former Intel CEO Pat Gelsinger to discuss the next wave of semiconductor innovation and the physical constraints shaping the AI buildout.Drawing on his experience designing Intel's 386 and 486 processors, Pat explains how AI could transform chip design, …

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Oct 8, 2026 · UTC

Building the Cloud for an Agentic World | AWS CEO Matt Garman

a16z’s Raghu Raghuram sits down with AWS CEO Matt Garman to discuss how AI is reshaping the cloud, from the needs of AI-native startups to infrastructure increasingly designed for agents.Matt explains how AWS is adapting as agents write code and manage infrastructure, why it’s reserving scarce GPU capacity for startups, and where custom chips like …

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